Itraconazole (Itrotab 200) 200 mg Capsules – 4 tablets

$5.73

Itraconazole (Itrotab 200) 200 mg capsules is an antifungal that destroys the fungal cell membrane and acts to prevent the growth of fungi. It is used to treat diseases that are caused by fungi in various parts of the body. Each capsule contains 200 mg of Itraconazole as an active ingredient.

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Itraconazole (Itrotab 200) 200 mg capsules is an antifungal that destroys the fungal cell membrane and acts to prevent the growth of fungi. It is used to treat diseases that are caused by fungi in various parts of the body. Each capsule contains 200 mg of Itraconazole as an active ingredient.

Drug = Itraconazole

Strength = 200 mg

How to take

Itraconazole is available as a tablet, capsule (conventional or pulse-release form), or as an oral solution.

If you have been given the tablet, conventional capsule or pulse-release capsule, take it immediately after a meal. Swallow it whole. Do not divide, chew, crush or break the tablet or capsule.

Try to take it at the same time each day. It must be taken regularly for it to be effective. 

Take exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor. Do not stop taking it unless instructed by the doctor.

Dosage of Itraconazole (Itrotab 200) 200 mg Capsules

Nail fungal infections:

Adult: As cap: 200 mg once daily for 90 days. As pulse treatment: 200 mg twice a day for seven days, repeated once for fingernails and twice for toenails after drug-free intervals of 21 days.

Pityriasis Versicolor:

Adult: As cap: 200 mg once daily for seven days.

Primary or secondary prophylaxis of infections in neutropenic or AIDS patients:

Adult: As cap: 200 mg daily, may increase to 200 mg twice a day if necessary.

Tinea corporis, Tinea cruris:

Adult: As cap: 100 mg once daily for 15 days or 200 mg once daily for seven days.

Oropharyngeal candidiasis:

Adult: As cap: 100 mg once daily for 15 days. In patients with AIDS or neutropenia: 200 mg once daily for 15 days.

Systemic fungal infections:

Adult: As cap: 100-200 mg once daily, may increase to 200 mg twice a day for invasive or disseminated infections. In life-threatening infections: As cap: Loading dose: 200 mg three times a day for three days.

Tinea manuum, Tinea pedis:

Adult: As cap: 100 mg once daily for 30 days. As pulse treatment: 200 mg twice a day for seven days.

Vulvovaginal candidiasis:

Adult: As cap: 200 mg twice a day for one day.

Missed Dose of Itraconazole (Itrotab 200) 200 mg Capsules

If you often forget to take your medicine, let your doctor and pharmacist know.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your usual dosing schedule.

Do not double a dose under any circumstances.

Overdose of Itraconazole (Itrotab 200) 200 mg Capsules

If you think you may have used Itraconazole more than the usual dose, please seek medical help immediately.

Contraindications

People with the following medical conditions should not take Itraconazole:

  • Hypersensitivity
  • History of Congestive Heart Failure
  • Pregnancy (non-life-threatening infection)

 

Side Effects of Itraconazole (Itrotab 200) 200 mg Capsules

Itraconazole may have the following side effects:

  • Heart failure
  • Pulmonary edema
  • Neuropathy
  • Transient or permanent hearing loss
  • Transient asymptomatic decrease of left ventricular ejection fraction (LVEF)
  • Hepatotoxicity
  • Hypersensitivity reactions
  • Granulocytopenia
  • Leukopenia
  • Thrombocytopenia
  • Chest pain
  • Tachycardia
  • Tinnitus
  • Visual disturbance
  • Blurred vision
  • Diplopia
  • Nausea
  • Abdominal pain
  • Vomiting
  • Diarrhea
  • Dyspepsia
  • Constipation
  • Edema
  • Fatigue
  • Pyrexia
  • Jaundice
  • Hepatitis
  • Hyperbilirubinemia
  • Urticaria
  • Elevated liver enzymes
  • Increased serum creatine phosphokinase
  • Hypokalemia
  • Hypertriglyceridemia
  • Myalgia
  • Arthralgia
  • Headache
  • Dizziness
  • Paresthesia
  • Dysgeusia
  • Pollakiuria
  • Urinary incontinence
  • Menstrual disorder
  • Erectile dysfunction
  • Dyspnea
  • Cough
  • Sinusitis
  • Rhinitis
  • Rash
  • Pruritus
  • Photosensitivity
  • Alopecia
  • Hypertension
  • Hypotension

Potentially Fatal: 

  • Acute liver failure (rare)

Warnings

Do not take Itraconazole with the following medicines:

  • Carbamazepine
  • Phenobarbital
  • Phenytoin 
  • Isoniazid
  • Rifabutin
  • Rifampicin
  • Nevirapine
  • Efavirenz
  • Antimuscarinics
  • Antacids
  • Proton Pump Inhibitors
  • Histamine H2-receptor antagonists
  • Indinavir
  • Ritonavir
  • Telaprevir
  • Erythromycin
  • Clarithromycin
  • Ciprofloxacin
  • Meloxicam
  • Digoxin
  • Alfentanil
  • Oxycodone
  • Repaglinide
  • Bilastine
  • Alprazolam
  • Midazolam (IV)
  • Buspirone
  • Saquinavir
  • Praziquantel
  • Bosentan
  • Aprepitant
  • Reboxetine
  • Fesoterodine
  • Solifenacin
  • Tamsulosin
  • Tadalafil
  • Sildenafil
  • Cinacalcet
  • Tolvaptan
  • Busulfan
  • Docetaxel
  • Trimetrexate
  • Vinca alkaloids
  • Ciclosporin
  • Tacrolimus
  • Budesonide
  • Dexamethasone
  • Fluticasone
  • Apixaban
  • Cilostazol
  • Coumarins
  • Fentany
  • Verapamil

Potentially Fatal: 

  • Astemizole
  • Bepridil
  • Cisapride
  • Disopyramide
  • Dofetilide
  • Dronedarone
  • Felodipine
  • Halofantrine
  • Lercanidipine
  • Levacetylmethadol
  • Mizolastine
  • Nisoldipine
  • Pimozide
  • Quinidine
  • Sertindole
  • Terfenadine
  • Dihydroergotamine
  • Ergometrine 
  • Simvastatin
  • Lovastatin 
  • Triazolam 
  • Midazolam (oral)
  • Lurasidone
  • Irinotecan
  • Eplerenone
  • Ranolazine
  • Colchicine 

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.

This list does not include all medicines that may interact with Itraconazole.

How Does It Work?

Itraconazole inhibits the cytochrome P-450 enzyme and ergosterol biosynthesis is reduced, resulting in the fungus being unable to build a cell membrane to protect itself. Ergosterol is an important component of the fungal cell membrane and its deficiency will allow the drug to cross freely and exert its effect by causing cellular permeability to increase.

Uses 

Itraconazole is used to treat the following conditions:

  • Esophageal candidiasis
  • Oral candidiasis 
  • Prophylaxis of fungal infections in immunocompromised patients 
  • Oropharyngeal candidiasis 
  • Vulvovaginal candidiasis 
  • Pityriasis Versicolor 
  • Tinea corporis
  • Tinea cruris 
  • Nail fungal infections 
  • Systemic fungal infections 
  • Prophylaxis of infections in neutropenic or AIDS patients

Special Precautions and Connected Warnings

Take special precautions if you have the following conditions:

  • Ischemic or valvular disease
  • Edematous disorders
  • Renal failure
  • Chronic obstructive pulmonary disease (COPD)
  • Achlorhydria
  • Immediate life-threatening systemic fungal infections
  • Cystic fibrosis
  • Neutropenic
  • Acquired immunodeficiency syndrome (AIDS)
  • Organ transplant patients
  • Renal and hepatic impairment
  • Elderly
  • Pregnancy (life-threatening infection) 
  • Lactation

Storage Conditions

  • Cap, tab: Store between 15-25°C and protected from light and moisture. 
  • Store in a cool, dry place away from the reach of children.
  • Do not use Itraconazole that is expired or out of date.