Letrozole (Femara) 2.5mg Tablet is a non-steroidal type II aromatase inhibitor used to treat breast cancer for those who no longer have menstrual period.
Letrozole may be used to treat other conditions as decided by your doctor.
Drug = Letrozole
Strength = 2.5mg
Manufacturer =Cipla
Quantity per sleeve = 50 Tabs (for the price quoted)
How To Take Letrozole (Femara) 2.5mg Tablet
This medicine may be taken with or without food. Try to take it at the same time each day.
Letrozole must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take Letrozole exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Dosage of Letrozole (Femara) 2.5mg Tablet
Advanced breast cancer in postmenopausal women; Adjuvant therapy for postmenopausal women with hormone receptor positive early breast cancer In hormone receptor positive postmenopausal women: 2.5 mg once daily.
Missed Dose
If you often forget to take your medicine, let your doctor and pharmacist know.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your usual dosing schedule.
Do not double a dose under any circumstances.
Overdose
If you think you may have used Letrozole more than the usual dose, please seek medical help immediately.
Contraindications of Letrozole
People with the following medical conditions should not take Letrozole:
- Premenopausal status
- Pregnancy
- Lactation
Side Effects of Letrozole
Letrozole may have the following side effects:
- Decreased bone mineral density
- CNS depression
- Hypercholesterolemia
- Dizziness
- Insomnia
- Somnolence
- Fatigue
- Headache
- Hypertension
- Peripheral edema
- Myocardial infarction
- Nausea
- Anorexia
- Increased appetite
- Dyspepsia
- Constipation
- Abdominal pain
- Diarrhea
- Vomiting
- Dyspnea
- Cough
- Increased liver enzymes
- Vag bleeding
- Hot flushes
- Weight gain
- Thrombocytopenia
- Osteoporosis
- Bone fracture
- Arthralgia
- Myalgia
- Sweating
- Alopecia
- Erythematous
- Psoriasiform
- Maculopapular or vesicular rash
- Dry skin
Warnings of Letrozole (Femara) 2.5mg Tablet
Do not use in people with the following conditions:
- Pregnancy
- Lactation
- Menstrual cycle is still normal
Inform your doctor and pharmacist if you are taking medicines:
- Estrogen containing drugs
- Tamoxifen
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
This list does not include all medicines that may interact with Letrozole.
How Does It Work?
Letrozole is a non-steroidal aromatase enzyme inhibitor which competitively binds to the haem of the CYP enzyme, blocking the conversion of androstenedione and testosterone into oestriol and oestradiol respectively, thus, leading to significantly reduced serum oestrogen concentration.
Uses
Letrozole is used to treat the following conditions:
- Advanced breast cancer in postmenopausal women
- Adjuvant therapy for postmenopausal women with hormone receptor positive early breast cancer
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Patient with history of osteoporosis and/or fracture
- Severe hepatic impairment (Child-Pugh score C) or cirrhosis
- Avoid alcohol
Storage Conditions
- Store at 25°C. Protect from moisture.
- This is a cytotoxic drug. Follow applicable procedures for receiving, handling, admin, and disposal.
- Store in a cool, dry place away from the reach of children.
- Do not use Letrozole that is expired or out of expiry date.
