Tadalafil is a phosphodiesterase-5 (PDE5) inhibitor prevalently used in the treatment of erectile problems. This drug also treats pulmonary hypertension, a type of high blood pressure that affects the arteries in the lungs.
Tadalafil acts by specifically inhibiting the enzyme phosphodiesterase type 5 ( PDE5), which is responsible for the smooth muscle metabolism of cyclic guanosine monophosphate ( cGMP). The inhibition led to an rise in cGMP levels during sexual arousal, causing smooth muscle relaxation and increased blood flow to the penis corpus cavernosum, resulting in an erection. It also relaxes the smooth muscle in the pulmonary vascular area , causing vasodilatation and diminished vascular resistance in the lung.
Drug = Tadalafil
Strength = 20 mg
Manufacturer = macleods
Quantity per sleeve = 4 Tablet (for the price quoted)
How To Take Tadalafil (Megalis) 20 mg Tablet
This medicine may be taken with or without food.
Try to take it at the same time each day. It must be taken regularly for it to be effective.
Take exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor. Do not stop taking it unless instructed by the doctor.
Dosage of Tadalafil (Megalis) 20 mg Tablet
Adult: Erectile dysfunction: Initially, 10 mg as needed, at least 30 minutes before sexual intercourse, may be increased to 20 mg depending on response. Alternatively, 5 mg once daily, taken each day simultaneously, may be decreased to 2.5 mg, depending on response. The maximum dosing frequency is once every 24 hours.
Benign prostatic hyperplasia: 5 mg once daily, taken at the same time each day.
Pulmonary arterial hypertension: 40 mg once daily.
Missed Dose of Tadalafil (Megalis) 20 mg Tablet
If you often forget to take your medicine, let your doctor and pharmacist know.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your usual dosing schedule.
Do not double a dose under any circumstances.
If you think you may have used Tadalafil more than the usual dose, please seek medical help immediately.
People with the following medical conditions should not take Tadalafil:
- Mild to severe heart failure
- Acute recent myocardial infarction
- Other conditions wherein the sexual activity is inadvisable
- Recent stroke
- Uncontrolled arrhythmias and hypertension
- Unstable angina
- Vision loss due to non-arteritic anterior ischaemic optic neuropathy (NAION)
- Severe hepatic impairment (Child-Pugh class C) when used for pulmonary arterial hypertension.
Side Effects of Tadalafil (Megalis) 20 mg Tablet
Tadalafil may have the following side effects:
- Transient ischemic attack
- Anginal chest pain
- Color discrimination impairment
- Vision lose/NAION
- Sudden decrease or loss of hearing
- Prolonged/painful erection or priapism (rare)
- Transient amnesia (rare)
- Peripheral edema
- Abdominal pain
- Gastroesophageal reflux disease
- Nasal congestion
- Respiratory tract infection
- Back and limb pain
- Pain in extremities
- Blurred vision
- Eye pain
- Myocardial infarction
- Sudden cardiac death
- Unstable angina pectoris
- Ventricular arrhythmia
Warnings of Tadalafil (Megalis) 20 mg Tablet
Do not take Tadalafil with the following medicines:
- Alpha 1-adrenergic blockers
- Azole antifungals
- HIV protease inhibitors
- Organic nitrates
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements, and medicines that you buy without a prescription.
This list does not include all medicines that may interact with Tadalafil.
How Does It Work?
Tadalafil works by selectively inhibiting the phosphodiesterase type 5 (PDE5) enzyme responsible for the metabolism of cyclic guanosine monophosphate (cGMP) in the smooth muscle. The inhibition led to an increase in cGMP levels, causing smooth muscle relaxation and increased blood flow into the corpus cavernosum of the penis during sexual stimulation, thereby producing an erection. It also relaxes the smooth muscle in the pulmonary vascular bed, causing vasodilation and reduced pulmonary vascular resistance.
Tadalafil is used to treat the following conditions:
- Erectile dysfunction
- Benign prostatic hyperplasia
- Pulmonary arterial hypertension
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Patient with retinitis pigmentosa
- Aortic stenosis
- Hypertrophic obstructive cardiomyopathy
- Anatomical penile deformation
- Sickle cell anemia
- Multiple myeloma
- Bleeding disorders
- Peptic ulcer disease
- Pulmonary veno-occlusive disease
- Renal and hepatic impairment
- Pregnancy and lactation
- Store below 25°C.
- Store in a cool, dry place away from the reach of children.
- Do not use Tadalafil that is expired or out of date.