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What does drug interaction mean for Tadalafila”?

One of the most interesting aspects about drug medications are the dynamic and complex mechanisms that help them to function properly in the healing process. Some have positive impacts while others can have negative effects. One such mechanism is interaction and using tadalafila as an example, interaction is when a substance interacts with tadalafila and interferes with its proper functioning making it less effective in treating a condition. Let’s delve into the mechanism aspect of drug medication.

Drugs that interact with tadalafila

It’s very important that you obtain as much information about these interactive drugs from your doctor or pharmacist. Examples of drugs that are capable of causing interactions with tadalafila are listed below:

Nitrates or angina drugs

Taking tadalafila with nitrate drugs can cause your blood pressure to drop dramatically to highly dangerous low levels.

This development can give you dizzy spells or can actually cause you to faint. Nitrate drugs include:

  • butyl nitrite
  • nitroglycerin
  • amyl nitrite
  • isosorbide mononitrate
  • isosobide dinitrate

Prostate or high blood pressure drugs

These drugs are also called alpha blockers and their interactive effects can be very dangerous as they can suddenly make your blood level drop to an alarming level that can cause you to feel dizzy or faint. These drugs include;

  • alfuzosin
  • terazosin
  • prazosin
  • tamsulosin
  • doxazosin

Some HIV drugs

When you take tadalafila with some HIV drugs, they can boost the levels of tadalafila in your blood. This may result in lowering you blood pressure causing dizziness and fainting together with vision issues.

I can also lead to priapism in men as they are also known as protease inhibitors which include:

  • lopinavir/ritonavir
  • ritonavir

Antifungal drugs (oral)

The taking of certain antifungal drugs may also increase the levels of tadalafila in your blood which in turn can lead to low pressure levels.

The low pressure levels can cause dizziness and fainting together with problems with your vision and in men it can lead to priapism or a very painful erection that can last for over 4 hours.

  • Ketoconazole
  • Itraconazole


There are certain antibiotic medicines which, when taken in combination with tadalafila, can cause the level of tadalafila in your blood to increase.

The drug’s increase in the blood can cause a low drop in your blood pressure which will give you feelings of dizziness and fainting, together with vision problems.

When the drop to low blood pressure occurs in men, it can result in priapism that involves a very painful erection that can last for more than 4 hours.

Some of these drugs include:

  • clarithromycin
  • telithromycin
  • erythromycin

Some other antibiotics can decrease the level of tadalafila in your blood and this can stop tadalafila from working effectively to cure the treated condition. For now there’s only one drug in this category:

  • rifampin

Other ED (erectile dysfunction) drug medications

All these medications have the same curative properties as tadalafila.

When you take them in combination with tadalafila, they have the propensity to increase your risk of suffering from side effects.

Examples of these drugs include:

  • Sildenafil
  • vardenafil

Other drugs for pulmonary arterial hypertension (PAH)

Whenever you decide to take tadalafil with other types of PAH drug medications, you may experience a sudden drop in your blood pressure levels. Some of these drugs include:

  • riociguat

Acid drugs for the stomach

Ingesting these drug medications in combination with tadalafila, can prevent your body from easily absorbing tadalafila into the bloodstream.

One of the main results of this low absorption can be the inability of tadalafila to function properly in treating the condition it’s meant to treat.

An example of these drugs include:

  • magnesium hydroxide
  • aluminum hydroxide

Drugs for epilepsy

Some anti-seizure drugs for the treatment of epilepsy have the ability to lower the level of tadalafila present in the body.

This can have the effect of reducing the potency and therefore the efficacy of tadalafila in performing its healing work.

These type of drugs include:

  • phenobarbital
  • carbamazepine
  • phenobarbital

Warnings when using Tadalafila

Drug medication Tadalafila should be used with caution as it comes with severe allergic warnings when used that can include:

  • swelling of your lips, tongue and throat
  • an outbreak of rash
  • hives
  • breathing and swallowing problems

It’s very important not to take this drug medication if you suffer from an allergic reaction the first time you took it. It’s life-threatening and could be fatal if your take it again

Interaction with grapefruit

When you eat grapefruit or drink its juice, the levels of tadalafila in your blood can significantly increase. This occurrence can increase the risk of suffering from side effects.

Interaction with alcohol

When you are taking tadalafila, you should avoid drinking large amounts of alcohol.

When you take alcohol and tadalafila together, you can expect that your blood vessels will become dilated or widened.

This dilating effect of the blood vessels can cause your blood pressure to drop.

Warnings for people having certain health conditions

Heart disease: Engaging in sexual activity has the propensity to aggravate any heart conditions you may have. The risk is increased when you take tadalafia.

If you are suffering from a heart condition, you shouldn’t take tadalafila, especially if your doctor has advised you against engaging in sexual activity.

Prolonged erections: It’s known that tadalafila can cause priapism. This condition has the propensity to cause a very painful long term erections that may last for over 4 hours and more.

When it happens it’s regarded as a medical emergency that needs prompt medical attention.

You should talk to your doctor prior to using tadalafila if you suffer from a condition that’s likely to put you at a high risk of getting priapism.

 If you have these conditions you are at high risk of suffering from priapism if you take tadalafila:

  • problems of blood cells such as sickle cell anemia, multiple myeloma or leukemia
  • Peyronie’s disease (curved or deformed penis)

Vision problems:  this condition is known by its name retinitis pigmentosa, a very rare genetic eye disorder.

The use of tadalafila in treating this condition hasn’t been recorded so it use for treating this condition   isn’t recommended.

You should nevertheless inform your doctor if you’ve ever had loss of vision including a related condition known as NAION (non-arteritic anterior ischemic optic neuropathy).

If you’ve previously taken tadalafila for treating NAION, you may be at a greater risk for having a recurrence of NAION again.

Kidney disease/dialysis: if you are suffering from kidney issues or you are under dialysis treatment. Due to kidney failure in cleaning your fluids, discharging tadalafila from your body may be an obstacle.

Tadadalafila may therefore stay longer in your body and raise the risk of side effects and your doctor may arrange a lower dosage of tadalafila, frequency of each dose or not offer any prescription.


Drug medication is not only about the successful treatment of diseases and conditions and the saving of a life due to the efficacy and potency of a particular drug treatment. It’s also about the proper use of drug treatments to counteract any possible repercussions and consequences of not taking a medication properly and simply not adhering to warnings that are always announced for all cases of drug usage. We hope you’ve enjoyed your read and learned much.

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