Doxycycline (Doxrid) 100 mg Capsule is a broad-spectrum antibiotic that have less toxic side effects as with the other drugs in its class. Based on the findings of antibiotic resistance testing, it is used to treat a wide variety of bacterial infections. Each capsule contains 100 mg of Doxycycline as its active ingredient.
Drug = Doxycycline
Strength = 100 mg
How to take
Doxycycline is taken with or without food but due to the nature of the medication that causes gastric upset it is best taken on a full stomach. DO NOT lie down immediately after taking the medication. Remain upright for at least 30 minutes.
Take Doxycycline as prescribed by your physician. Do not take more than the recommended dose.
Dosage of Doxycycline (Doxrid) 100 mg Capsule
Adult: Severe infections: 200 mg/day for a period of 7 to 10 days depending upon the individual response.
Sexually transmitted diseases; Uncomplicated gonorrhea: 100 mg twice a day for seven days.
Epididymo-orchitis (infection of the male reproductive system) due to Chlamydia trachomatis or Neisseria gonorrhoeae: 100 mg twice a day for 10 days.
Syphilis: 300 mg/day for at least ten days.
Relapsing fever and louse-borne typhus: 100 or 200 mg as a single dose.
Prophylaxis of scrub typhus: 200 mg as a single dose.
Chloroquine-resistant falciparum malaria acute attack: In combination with quinine: 200 mg/day for at least seven days.
Prophylaxis of malaria: 100 mg/day started 5 days before travel to malaria endemic area and for another 2 weeks after leaving the area.
Treatment and postexposure prophylaxis of inhalation anthrax: 100 mg twice a day for 60 days.
Prophylaxis for traveller’s diarrhea: 200 mg on the first day of travel, then 100 mg/day.
Prophylaxis for leptospirosis: 200 mg/week throughout the trip, then 200 mg on the last day of the trip.
Acne vulgaris: 50 mg/day for 6-12 weeks.
Periodontitis: 20 mg twice a day for up to 3 months.
Missed Dose of Doxycycline (Doxrid) 100 mg Capsule
In the event that the dose is missed, take the tablet immediately and skip the dose for the day. Resume taking the medication the next day at the same time.
Inform your doctor for dose readjustment.
Overdose of Doxycycline (Doxrid) 100 mg Capsule
If you have taken Doxycycline more than the recommended dose, seek professional help immediately.
Contraindications
People with the following medical conditions should not take Doxycycline:
- Hypersensitivity to doxycycline and its component
- Known or suspected achlorhydria (decreased gastric acid secretion, owed to the prolonged use of H2 blockers)
- Children 8 years old and younger (except for anthrax)
- Pregnant and lactating women
Side Effects
Doxycycline may have the following side effects:
- Microbial overgrowth including fungi
- Pseudomembranous colitis
- Esophageal ulceration
- Discoloration of teeth
- Exfoliative dermatitis
- Drug reaction with eosinophilia and systemic symptoms
- Jarisch-herxheimer Reaction (in cases of syphilitic reaction)
- Transient increase in liver enzymes(rare)
- Hemolytic anemia
- Decreased white blood and platelet counts (neutrophils, eosinophils)
- Eosinophilia
- Rapid heart rate
- Ringing of the ears
- Changes in vision (blurring, doubling of vision)
- Abdominal pain, diarrhea, vomiting
Potentially Fatal side effects
- Severe anaphylactic reaction
- Stevens-Johnson Syndrome
- Toxic epidermal necrolysis
- Clostridium Difficile-Associated Disease (CDAD)
- Hepatotoxicity
Warnings/Precautions:
Do not take Doxycycline with the following medicines:
- Isotretinoin
- Oral contraceptives
- Warfarin
- Antacids containing Al, Ca or Mg, Zn, Fe salts, bismuth preparations
- Carbamazepine
- Phenobarbital
- Phenytoin
- Primidone
- Ciclosporin
- Penicillin
- Rifampicin
Potentially Fatal combination
- Methoxyflurane
Inform your physician about the over the counter medications that you are currently taking prior to the administration of doxycycline.
This list does not include all medicines that may interact with Doxycycline.
How Does It Work?
Doxycycline acts as a bacteriostatic agent and prevents both gram negative and gram positive organisms from developing and replicating.
Uses
Doxycycline is used to treat the following conditions:
- Sexually transmitted diseases
- Uncomplicated gonorrhea
- Epididymo-orchitis due to Chlamydia trachomatis or Neisseria gonorrhoeae
- Relapsing fever and louse-borne typhus
- Prophylaxis of scrub typhus
- Chloroquine-resistant falciparum malaria acute attack
- Prophylaxis of malaria
- Treatment and postexposure prophylaxis of inhalation anthrax
- Prophylaxis of traveller’s diarrhea
- Prophylaxis of leptospirosis
- Acne
- Periodontitis
Special Precautions and Warnings
Take special precautions if you have the following conditions:
- Patient with coexisting venereal disease other than those mentioned above
- Myasthenia gravis
- Systemic Lupus Erythematosus
- Hepatic and renal impairment
- It is best to avoid taking dairy products while on doxycycline treatment
Storage Conditions
- Store between 20-25°C.
- Store in a cool, dry place away from the reach of children.
- Do not use Doxycycline after the date on the bottom of the packaging
